Urinary albumin-creatinine ratio（ UACR）， as a sensitive and reliable indicator for the diagnosis of early renal diseases， can reflect the systemic vascular endothelial dysfunction. It has been found that UACR level plays an important role in the occurrence， development and prognosis of atherosclerosis and ischemic stroke. There is some controversy on relationship between UACR level and ischemic stroke， though many scholars had conducted numerous studies in the last ten years. This paper reviews the relationship between UACR level and the risk and prognosis of ischemic stroke， in order to provide reference for improving clinical management of UACR level in patients with early renal disease.