重复经颅磁刺激对帕金森病患者双眼竞争 平均切换时间的影响
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国家自然科学基金项目(91432301);国家重点研发计划项目(2018YFC1314200)


Effect of repetitive transcranial magnetic stimulation on binocular rivalry in Parkinson disease
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    摘要:

    目的 探讨对帕金森病病患者辅助运动区进行重复经颅磁刺激(rTMS)的感知觉变化。 方法 回顾性连续纳入2018 年4—10 月于安徽医科大学第一附属医院神经内科门诊就诊的12 例帕金 森病患者(6 例男性,6 例女性),采用rTMS 的持续性θ爆发式磁刺激序列,在导航下对辅助运动区进行 连续14 d 的rTMS 治疗,治疗前后分别测定患者未服药状态下的双眼竞争平均切换时间,并采用汉密尔 顿焦虑量表(HAMA)、汉密尔顿抑郁量表17 项(HAMD-17)、统一帕金森病评定量表中第Ⅲ部分运动症 状评定量表(UPDRS Ⅲ)进行评定。结果 受试者治疗前UPDRS Ⅲ评分为(29.25±12.02)分,治疗后评 分为(24.00±11.63)分明显低于治疗前,差异有统计学意义(t=2.644,P < 0.05)。受试者治疗前HAMA、 HAMD-17 评分分别为(9.08±3.09)、(9.75±3.52)分,治疗后分别为(8.50±3.29)、(8.75±3.22)分,治疗前 后评分差异均无统计学意义(t值分别为1.074、1.225,均P> 0.05)。治疗前后受试者双眼竞争平均切换 时间为(5.50±1.47)、(4.06±1.21)s,治疗后的双眼竞争平均切换时间较治疗前明显缩短,差异有统计学 意义(t=3.743,P < 0.05)。结论 rTMS 干预帕金森病患者辅助运动区可加快帕金森病患者双眼竞争的 切换,提高其感知觉水平。

    Abstract:

    Objective Using binocular competition paradigm to study sensory perception, so as to explore whether repetitive transcranial magnetic stimulation( rTMS) can change the average switching time of binocular competition in patients with Parkinson disease. Methods A total of 12 patients with Parkinson disease( 6 males and 6 females) were enrolled in this study. All subjects received rTMS therapy for 14 days. The stimuli of rTMS therapy was persistent theta-burst stimulation, and the rTMS treatments were complemented under navigation. The average switching time for binocular rivalry, and the mean scores of Hamilton Anxiety Scale( HAMA), Hamilton Depression Scale-17( HAMD-17), Unified Pakinson disease Rating Scale Ⅲ (UPDRS Ⅲ) were evaluated without taking medicine before and after the treatment. Results The mean score of UPDRSⅢ before the treatment was( 29.25±12.02), while the mean score of UPDRSⅢ after the treatment was( 24.00±11.63). The difference was statistically significant( t=2.644, P<0.05). The mean scores of HAMA and HAMD-17 before the treatment were( 9.08±3.09) and( 9.75±3.52) respectively, while the mean scores of HAMA and HAMD-17 after the treatment were( 8.50±3.29) and( 8.75±3.22) respectively. The difference in HAMA and HAMD-17 scores before and after treatment was not statistically significant( t=1.074,1.225;P> 0.05). The average switching time for binocular rivalry before and after the treatment was( 5.50±1.47) s and (4.06±1.21) s respectively. The mean switching time of binocular competition after treatment was significantly shorter than that before treatment, and the difference was statistically significant( t=3.743,P < 0.05). Conclusions rTMS intervention on auxiliary motor area could accelerate the switching of binocular competition in patients with Parkinson disease.

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莫雨婷 邢峰博 刘萍萍 孙金梅 胡盼盼 汪凯.重复经颅磁刺激对帕金森病患者双眼竞争 平均切换时间的影响[J].神经疾病与精神卫生,2020,20(8):
DOI :10.3969/j. issn.1009-6574.2020.08.002.

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  • 在线发布日期: 2020-12-07