Objective Using binocular competition paradigm to study sensory perception, so as to explore whether repetitive transcranial magnetic stimulation( rTMS) can change the average switching time of binocular competition in patients with Parkinson disease. Methods A total of 12 patients with Parkinson disease( 6 males and 6 females) were enrolled in this study. All subjects received rTMS therapy for 14 days. The stimuli of rTMS therapy was persistent theta-burst stimulation, and the rTMS treatments were complemented under navigation. The average switching time for binocular rivalry, and the mean scores of Hamilton Anxiety Scale( HAMA), Hamilton Depression Scale-17( HAMD-17), Unified Pakinson disease Rating Scale Ⅲ (UPDRS Ⅲ) were evaluated without taking medicine before and after the treatment. Results The mean score of UPDRSⅢ before the treatment was( 29.25±12.02), while the mean score of UPDRSⅢ after the treatment was( 24.00±11.63). The difference was statistically significant( t=2.644, P<0.05). The mean scores of HAMA and HAMD-17 before the treatment were( 9.08±3.09) and( 9.75±3.52) respectively, while the mean scores of HAMA and HAMD-17 after the treatment were( 8.50±3.29) and( 8.75±3.22) respectively. The difference in HAMA and HAMD-17 scores before and after treatment was not statistically significant( t=1.074,1.225;P> 0.05). The average switching time for binocular rivalry before and after the treatment was( 5.50±1.47) s and (4.06±1.21) s respectively. The mean switching time of binocular competition after treatment was significantly shorter than that before treatment, and the difference was statistically significant( t=3.743,P < 0.05). Conclusions rTMS intervention on auxiliary motor area could accelerate the switching of binocular competition in patients with Parkinson disease.
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莫雨婷 邢峰博 刘萍萍 孙金梅 胡盼盼 汪凯.重复经颅磁刺激对帕金森病患者双眼竞争 平均切换时间的影响[J].神经疾病与精神卫生,2020,20(8): DOI :10.3969/j. issn.1009-6574.2020.08.002.