Alzheimer disease is a kind of neurodegenerative disorder characterized by memory loss and cognitive impairment. Due to the inefficiency of traditional drug therapy， cell therapy is a new way to treat Alzheimer disease. In view of the fact that current research on Alzheimer disease mainly focuses on the mechanism of tool cell therapy for Alzheimer disease and tool cell screening， there is little summary of transplantation methods. In this paper， the methods of tool cell transplantation are summarized.