Objective To explore the difference of the influence of family function on quality of life between first-episode and relapsing schizophrenia. Methods A total of 46 first-episode and 88 relapsing schizophrenias which met the inclusion and exclusion criteria were recruited by convenience sampling method in the inpatient department of mental health center， West China Hospital， Sichuan University from July 2018 to December 2018. General information， Family Assessment Device（ FAD， including communication， role， problem solving， emotional response， emotional intervention， behavior control and total function）， Family Adaptability and Cohesion Evaluation ScaleⅡ China Version（ FACESⅡ-CV， including intimacy and adaptability） and Schizophrenia Quality of Life Scale（ SQLS， including psychosocial， motivation and energy， symptoms and side effects） were applied to compare between groups. Correlation analysis and multiple stepwise regression analysis were used to analyze the influence of family function on the quality of life of the two groups and to explore the differences. Results There were statistically significant differences in family communication and cohesion between first-episode and relapsing schizophrenia（ t=2.45，-2.14；P＜ 0.05）. SQLS total scores was correlated with all dimensions of FAD and FACES in relapsing schizophrenia（ P＜0.05）， while in first-episode patients， only communication（ r=0.32， P ＜ 0.05） and general function（ r=0.32，P ＜ 0.05） were related to motivation and energy. For first-episode schizophrenias， family communication（ β=0.32，P=0.03） was influencing factor of quality of life， while in relapsing schizophrenias， general functions（ β=0.29， P=0.02） and roles（ β=0.24， P=0.04） affected their quality of life. Conclusions The quality of life of first-episode schizophrenias with poor family communication is lower， while in relapsing schizophrenias， poor family roles and general family function is correlated with lower quality of life.