Cerebral ischemia injury involves a variety of pathological processes， in which protein acetylation is involved， and protein acetylation can activate autophagy. Histone deacetylase（ HDAC） is a family of enzymes that regulate the level of protein acetylation， among which HDAC 2/6 is the most representative subtype. This article mainly introduces the research progress of HDAC 2/6 and autophagy in cerebral ischemia injury.