Objective To evaluate the prevalence of postpartum sleep disorders and postpartum depression in women， and to explore the relationship between postpartum sleep disorders and postpartum depression. Methods A cross-sectional study design was used to investigate the basic data of 252 women who underwent reexamination after childbirth in Xijing Hospital from January 2017 to December 2018. The Pittsburgh Sleep Quality Index（ PSQI） and the Edinburgh Postpartum Depression Scale（ EPDS） were used to evaluate sleep quality and postpartum depressive symptom. EPDS ＞ 9.5 was defined postpartum depression. According to whether postpartum depression occurred， 252 cases were divided into postpartum depression group and non-depression group. Rusults The prevalence of sleep disorders and postpartum depression were 36.1% （91/252） and 25.8%（ 65/252）， respectively. In uni-variate analysis， the PSQI score of postpartum depression group was significantly higher than that of non-depression group［ （8.43±2.37） vs（. 5.76±1.84）；t=9.293，P＜ 0.01］； Except for sleep time subscale， PSQI subscale scores of postpartum depression group were higher than those of non-depression group（ all P＜0.01）； The prevalence of sleep disorder（ PSQI ＞ 7） in postpartum depression group was significantly higher than that in non-depression group［ 52.3%（ 34/65） vs. 30.5%（ 57/187）； χ2=9.960， P=0.002］. Multivariate logistic regression analysis showed that the association between postpartum sleep quality and postpartum depression remained significant after adjusting for sociodemographic variables， perinatal variables and gestational disease variables（ OR=2.35， 95%CI：1.32-4.21）. Conclusions Postpartum sleep disorders were positively associated with postpartum depression. Interventions should be provided as early as possible to reduce the risk of depression for women with postpartum sleep disorders.