Objective To investigate the efficacy and safety of high-frequency repetitive transcranial magnetic stimulation（ rTMS） in the treatment of post-withdrawal anxiety， depression and hunger in methamphetamine（ MA） dependent patients. Methods A total of 47 cases of male MA dependent detoxification patients in Bengbu Compulsory Isolation and Rehabilitation Center were prospectively selected. All the subjects were divided into study group and control group according to the random number table method. The study group received systematic high-frequency（ 10 Hz） rTMS treatment， while the control group received sham rTMS treatment for 3 times a week and a total of 4 weeks. Self-rating Anxiety Scale（ SAS）， Self-rating Depression Scale（ SDS） and Visual Analogue Scale（ VAS） were used to assess anxiety， depression and psychological craving at baseline and at the end of the fourth week of treatment， respectively. Adverse drug reactions were recorded by adverse drug reactions questionnaire（ ADR） during the intervention. Rusults At the end of the fourth week of treatment， SAS score（ 43.17±8.60）， SDS score（ 48.00±8.12） and VAS score［ 1.00（ 0，2.75）］ in the study group were lower than those at baseline［ SAS score（ 46.71±8.64）， SDS score（ 52.96±7.66） and VAS score 4.00（ 2.00，5.75）］with statistically significant differences（ all P＜0.05）. SAS score， SDS score and VAS score of the study group at the end of the fourth week of treatment were all lower than those of the control group［ （48.74±8.92）， SDS scores（ 53.13±6.61） and VAS scores 4.00（0， 6.00）］with statistically significant differences（ P ＜0.05）. There was no statistically significant difference in SAS， SDS and VAS scores of the control group at the end of the fourth week compared with those at baseline（ all P＞0.05）. There were 8 cases （33.33%） of adverse reactions in the study group， including 6 cases of headache， 1 case of dizziness and 1 case of tinnitus， which could be tolerated by the patients； no adverse reactions occurred in the control group. Conclusions High-frequency rTMS can improve the anxiety， depression and craving of methamphetaminedependent patients. Mild adverse reactions are common.