Although a large number of antipsychotics are used for the treatment of mental disorders currently， the compliance of patients is poor due to the adverse drug reactions， administration methods， and other factors. Transdermal drug delivery can reduce the first-pass effect of liver， avoid gastrointestinal irritation， make the blood concentration more stable， and is convenient， because of which the compliance of patients is greatly increased. Blonanserin is a second generation antipsychotic drug， which can improve the positive， negative and cognitive symptoms of schizophrenia effectively. Blonanserin transdermal patch has completed phase 3 clinical trials， with high efficacy and safety，and there are great prospects for drug treatment of mental disorders. In this paper， the research status of blonanserin transdermal patch is reviewed.