The incidence rate of autism has been increasing year by year. Because of the complexity of its pathogenic causes， the study of autism has become difficult. Studies show that genetic factors account for 50% of the incidence rate of autism. However， there were few animal models that could effectively reflect the etiology. This article reviews the animal models of genotype autism based on copy number variation（ CNV） and single nucleotide variation（ SNVs）， as a new advanced model tool to understand the mechanism of autism in the future.