Antidepressant combined therapy strategy， that is， the use of two antidepressants at the same time， is a treatment option often used in clinic， especially with the significant improvement of the safety of the new generation of antidepressants. At present， the combination of selective serotonin reuptake inhibitors and different antidepressants has been widely used in patients who do not respond to monotherapy. At the same time， in order to shorten the onset time and improve the cure rate， the combination therapy has also been applied to the initial or early treatment stage of depression. Combined treatment strategy benefits patients， but also has the risk of increasing adverse reactions. Therefore， it is necessary to further evaluate the benefits and risks of antidepressant combination therapy in different periods. This article reviews the clinical research of antidepressant combination therapy for depression， in order to provide reference for the combination therapy of depression.