In recent years， the inflammatory hypothesis of depression has become a hotspot of research. More and more evidences show that the changes of inflammatory factors play an important role in the occurrence and development of depression.In addition， there are limitations to the effectiveness of current antidepressants， while adjuvant anti-inflammatory therapy has shown preliminary antidepressant effects in laboratory and clinical studies， even in treatment-resistant depression， which shows new hope for the current basis of depression and drug research.This review summarizes recent research on depression， inflammatory factors and adjuvant antiinflammatory therapy.