Objective To explore the effect of comprehensive intervention on burden of care and quality of life of Alzheimer disease caregivers. Methods From January 2020 to June 2020， 180 caregivers were recruited from the elderly clinic of Chongqing Mental Health Center. They were randomized into comprehensive intervention group（ 90 cases） and control group（ 90 cases）. The study group received comprehensive intervention， and the control group received supportive psychological intervention. Zarit Caregiver Burden Interview（ ZBI） and WHO Quality of Life Scale BREF（ WHOQOL-BREF） were used before intervention and 3 and 6 months after intervention. Results The results of repeated measurement ANOVA showed that there were statistically significant in ZBI and WHOQOL-BREF scores between the two groups（ F=4.365，5.446； P＜0.05）. The differences in time main effec（t F=328.428， 24.779； P＜0.05） and interaction（ F=26.170，21.786； P＜0.05） were statistically significant. Conclusions Comprehensive intervention can reduce the burden of care and improve the quality of life of Alzheimer disease caregivers.