Moderate stress is beneficial to the survival and development of individuals. But it will lead to chronic stress， social dysfunction and increase the risk of mental illness， especially anxiety disorders and related disorders when the stress level beyond what an individual can bear or repeated exposure to stress. Current research has found that dysregulation of the oxytocinergic system is associated with the development and maintenance of anxiety related psychiatric disorders. This article describes the relationship between oxytocin （OXT） and anxiety disorder related social dysfunction， the mechanism of oxytocin in anxiety disorder related diseases， and the progress and deficiency of related research， hoping to help improve the understanding of anxiety disorder related diseases， provide information for the future research of oxytocin system， and develop individualized prevention and treatment strategies based on oxytocin treatment.