PTPN7在人脑胶质瘤中的表达及临床意义
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国家自然科学基金项目(82003192)


Expression and clinical significance of PTPN7 in glioma
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    摘要:

    目的 探究脑胶质瘤的潜在预后分子标志物,并为精准治疗提供理论依据。方法 纳 入CGGA 与TCGA 两个独立数据库病例,其中CGGA 数据库病例325 例,TCGA 数据库病例636 例,分析 PTPN7 表达水平同脑胶质瘤病理级别、IDH突变状态、4 个分型亚型以及预后的关系,并通过基因本体 (GO)功能富集分析探讨PTPN7 在脑胶质瘤中的潜在功能。结果 通过CGGA 与TCGA数据库的分析证 实,PTPN7 表达水平随胶质瘤恶性级别升高明显上调(WHO Ⅳ级最高,P< 0.05),在IDH 野生型的胶质 瘤中表达水平高于IDH突变型(P<0.05),且在恶性程度最高的间质型中PTPN7表达明显上调(P<0.05); KM 生存分析证实,PTPN7可以区分患者预后,PTPN7高表达的患者预后较差(P< 0.05);GO 功能富集分 析证实,PTPN7正相关的基因更多地富集在免疫反应、凋亡、黏附、增殖、蛋白水解、蛋白磷酸化、趋化性、 药物反应性及血管生成等多个与脑胶质瘤恶性进展相关的功能中。结论 PTPN7可以预测脑胶质瘤患 者的恶性预后,同脑胶质瘤的恶性进展密切相关,该基因可作为未来靶向治疗的新靶点。

    Abstract:

    Objective To explore the potential prognostic molecular markers of glioma and provide theoretical basis for precise treatment. Methods In this study, two independent datasets( CGGA and TCGA) were used to analyze and verify the relationship between the expression level of Protein Tyrosine Phosphatase Non-receptor type 7( PTPN7) and the pathological grade, IDH mutation status, subtypes and prognosis( CGGA 325 cases and TCGA 636 cases). GO analysis was used to explore the potential functions of PTPN7 in glioma. Results It was confirmed by CGGA and TCGA databases that the expression level of PTPN7 was significantly increased with the increase of malignant grade of glioma( highest in WHOⅣ, P<0.05). The expression level of PTPN7 in IDH wild-type glioma was higher than that of IDH mutant, and was up-regulated in mesenchymal subtype( P<0.05). KM survival analysis confirmed that PTPN7 could distinguish the prognosis of patients, and the prognosis of patients with high expression of PTPN7 was poor( P<0.05). GO functional enrichment analysis confirmed that the positively related genes of PTPN7 were enriched in immune response, apoptotic process, cell adhesion, proliferation, proteolysis, protein phosphorylation, chemotaxis, response to drug, angiogenesis and other functions related to malignant progression of glioma. Conclusions PTPN7 can predict the malignant prognosis of glioma patients, and is related with the malignant progression of glioma. This gene can be used as a new target for future targeted therapy.

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黄华 王宽宇. PTPN7在人脑胶质瘤中的表达及临床意义[J].神经疾病与精神卫生,2021,21(5):
DOI :10.3969/j. issn.1009-6574.2021.05.007.

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  • 在线发布日期: 2021-06-02