Intolerance of uncertainty， as a cross diagnostic risk factor， is associated with a variety of mental disorders， but the neural mechanism is still unclear. In order to further clarify the relationship between intolerance of uncertainty and brain function and structure， this paper reviews the research progress of MRI on intolerance of uncertainty， including the relationship between intolerance of uncertainty and brain regions such as insula， amygdala， anterior cingulate gyrus， prefrontal lobe and striatum.