Objective To explore the effect of cognitive behavioral therapy（ CBT） combined with medication on adolescent patients with generalized anxiety disorder（ GAD）. Methods A total of 68 adolescent patients with GAD aged 13-22 years were divided into CBT combined with medication group（ combined group） and medication group by random number table method， and were given 8 weeks medication treatment. Patients in the combined group were also given CBT once a week. Hamilton Anxiety Scale（ HAMA-14） and student- Life Stress Inventory（ SLSI） were used to evaluate the efficacy of both groups at baseline and the 4th and 8th week of treatment. Results 32 cases in the combined group and 24 cases in the medication group completed the study. At baseline， there was no statistically significant difference in age， sex， being the only child and years of education between the two groups（ P＞0.05）. After 4 weeks of treatment， HAMA-14 and SLSI score in combined group were lower than those in medication group（ t=-2.348，P=0.023；t=-3.014，P=0.003）. After 8 weeks of treatment， there were statistically significant differences in HAMA-14 score and SLSI score between the two groups（ t=-2.597，P=0.012；t=-3.639，P=0.001）. After 8 weeks of treatment， compared within each group， the HAMA-14 and SLSI scores of the combined group and the medication group were gradually decreased， and the differences were statistically significant（ HAMA-14： F=74.961，P＜0.05；F=37.614，P＜0.05； SLSI： F=28.818，P＜ 0.05；F=30.137，P＜ 0.05）. Conclusions CBT combined group and medication group can effectively relieve the anxiety symptoms of adolescent patients with GAD and improve the student life stress symptoms. The effect of CBT combined intervention is better than that of medication treatment alone.