As a new component of psychotherapy， interpersonal and social rhythm therapy has been widely used in the treatment and prevention of bipolar disorder abroad， and achieved remarkable results. However， there is still a lack of research on the application of interpersonal and social rhythm therapy in bipolar disorder in China. This paper reviews the definition and clinical manifestation of bipolar disorder， together with the theoretical basis， implementation process and application effect of interpersonal and social rhythm therapy， in order to provide reference for the psychotherapy of patients with bipolar disorder in China.