With the aging of the population， late-life depression has become an important disease affecting the physical and mental health of the elderly，which should be paid more attention to. The diagnosis of late-life depression is not clear， and its pathogenesis， clinical manifestation， treatment and outcome are very different from other types of depression. In recent years， the related literature on the treatment of late-life depression is increasing， but the conclusions are inconsistent. Therefore， based on the above problems， we will elaborate the relevant literature on the treatment of late-life depression， in order to provide ideas and reference for clinical work and future research.