Depressive disorder is one of the most common co-diseases of epilepsy. At present， the research in this field is in the ascendant， but the degree of clinical attention still needs to be improved. Patients with epilepsy have not been fully identified and diagnosed， and the quality of life declines. Studies have shown that epilepsy and depression have a common pathogenesis， including neurotransmitter regulation mechanism， neuro-immune regulation mechanism， brain network related mechanism and genetic related mechanism. This article reviews the research progress on the related mechanism of epilepsy comorbid depression