Objective To analyze the quality of life among children with tic disorders and the influencing factors. Methods A total of 150 children and adolescents aged from 4 to 15 years were enrolled in tic disorders group， who were first diagnosed with tic disorders in the Pediatric Outpatient Department of Renmin Hospital of Wuhan University from June 2019 to December 2020. Another 150 age- and gender-matched healthy children who underwent health examinations during the same period in the Child Healthcare Department of the same hospital were randomly selected as the control group. The Yale Comprehensive Tic Severity Scale （YGTSS） and the Achenbach Child Behavior Scale （CBCL） were used respectively to assess the tic disorders and behavioral status of all research subjects. The Pediatric Quality of Life Inventory 4.0， Generic Core Scales of the Chinese version （PedsQL） was used to assess the quality of life of the two groups. The generalized linear model was used to analyze the influencing factors of PedsQL total score and each part score in children with tic disorder. Results The subscale score of social-psychological domain of PedsQL was lower than the subscale score of physical domain among children with tic disorders. The subscale score of school performance of PedsQL in tic disorders group was significantly lower than that in control group （P＜ 0.05）. The results of the generalized linear models showed that the subscale score of physical functioning （physical domain） in tic disorders cases was positively correlated with democratic parenting pattern （β=0.102， 95%CI=0.009-0.196） and normal behavior （β=0.094， 95%CI=0.020-0.168） （P ＜ 0.05）. The subscale score of emotional functioning was positively correlated with personal physical fitness （β=0.128， 95%CI=0.006-0.250）， the education level of the mother is high school （β=0.118， 95%CI=0.018-0.217） or middle school and below （β=0.137， 95%CI=0.038-0.236）， and normal behavior （β=0.170， 95%CI=0.087-0.253） （P＜ 0.05）. The subscale scores of social functioning and social-psychological domain were positively correlated with normal behavior （β=0.106， 0.154；95%CI=0.039- 0.172， 0.091-0.217） （P ＜ 0.05）. The subscale scores of school performance was negatively correlated with the education level of the mother is middle school and below （β=-0.172，95%CI=-0.303- -0.041）， and positively correlated with normal behavior （β=0.246， 95%CI=0.147-0.344） （P＜ 0.05）. PedsQL total score was positively correlated with mild tic disorders （β=0.062， 95%CI=0.006-0.119） and normal behavior （β=0.135， 95%CI=0.077-0.192） （P ＜ 0.05）. Conclusions The school performance of children with tic disorders is worse than that of normal healthy children. The quality of life among children with tic disorders is significantly related to their personal physical fitness， parenting pattern， parental education levels and comorbid behavioral problems