Objective To explore the influence of family and other factors on suicidal behavior of adolescent depression patients. Methods A cross-sectional survey was conducted on 126 adolescent depression patients hospitalized in the Department of Child and Adolescent Psychology of Jingmen NO.2 People's Hospital from June 2020 to December 2021. The patients were divided into suicide group （n=76） and non-suicide group （n=50） according to whether they had committed suicide in the past 6 months. The general information questionnaire， Patient Health Questionnaire-9 （PHQ-9）， Self-Rating Idea of Suicide Scale （SIOSS）， the Chinese version of Family Adaptability and Cohesion Scale， Second Edition （FACES Ⅱ -CV） were applied to compare general information， depression degree， suicidal ideation and family classification. Spearman was used to analyze the correlation between suicidal behavior and general data， PHQ-9， SIOSS， and FACES Ⅱ -CV scores. Binary Logistic regression model was used to analyze the influencing factors of suicidal behavior. Results The drinking rate and family history of mental illness in the suicide group ［40.8% （31/76）， 27.6% （21/76）］were significantly higher than those in the non-suicide group ［20.0% （10/50）， 12.0% （6/50）］， and the differences were statistically significant （P ＜ 0.05）. The scores of PHQ-9， SIOSS total score， despair and sleep factor in the suicide group were higher than those in the non-suicide group ［19.0 （15.0，21.8） vs 15.0 （10.8，19.0）； 15.0 （14.0，16.8） vs 13.0 （11.0，15.0）； 12.0 （10.3，12.0） vs 10.0 （7.8，12.0）； 3.0 （2.0， 3.0） vs 2.0 （1.0， 3.0）］， and the family cohesion score was lower than that in the non-suicide group ［50.5 （43.3， 57.0） vs 57.5 （48.8，65.5）］， and the differences between the two groups were statistically significant （P ＜ 0.05）. In the suicide group， the rate of extreme family ［67.1% （51/76）］ was significantly higher than that of the non-suicide group ［44.0% （22/50）］， and the difference between the two groups was statistically significant （P ＜ 0.05）. The suicidal behavior was negatively correlated with family intimacy （r=-0.224， P ＜ 0.05）， and positively correlated with PHQ-9 score， SIOSS total score， despair factor score， sleep factor score， drinking behavior， and having family history of mental illness （r=0.346， 0.373， 0.361， 0.324， 0.206， 0.217， 0.186； P ＜ 0.05）. Binary Logistic regression analysis showed that alcohol consumption （OR=3.066， 95%CI=1.184-7.941）， high family adaptability （OR=1.126， 95%CI=1.034-1.227）， high PHQ-9 score （OR=1.197， 95%CI=1.087-1.317） were the risk factors for suicidal behavior of adolescent depression patients （P＜ 0.05）， and high family intimacy was the protective factor for suicidal behavior （OR=0.878， 95%CI=0.813- 0.948）. Conclusions Adolescent depression patients have a higher incidence of suicidal behavior. Family classifications are more common in "rigid-loose" extreme families. Alcoholic behavior， severe depression， and poor family relationships are more likely to commit suicide.