Objective To explore the coping style and general well-being of the main caregivers of schizophrenia patients with violence. Methods The main caregivers of 487 schizophrenic inpatients with violence hospitalized in Chongqing Mental Health Center from January 2014 to December 2016 were selected as the study group by continuous sampling method. The main caregivers of 479 schizophrenic patients without violence matched with the age， gender， years of education and course of disease of violent schizophrenic patients were selected as the control group. The coping style and general well-being of the main caregivers of schizophrenic patients with violence were evaluated by coping style questionnaire （CSQ） and general wellbeing scale （GWB）. Results The total GWB score of the study group was lower than that of the control group ［（101.92±10.43） vs （103.91±11.03）， P ＜ 0.05］. There was significant difference in the GWB scores of caregivers of patients with different violence style ［killing （99.54±11.06）， wounding （100.17±10.23）， smashing （103.03±10.28）， others （103.01±9.78）. There was no significant difference in the scores of various factors of CSQ （P ＞ 0.05）. The scores of withdraw ［（0.68±0.20） vs （0.65±0.21）］ in the study group were higher than those in the control group， while the scores of problem-solving ［（0.68±0.19） vs （0.72±0.18）］， self accusation ［（0.62±0.22） vs （0.65±0.22）， help seeking ［（0.57±0.18） vs （0.64±0.17）］， rationalization ［（0.70±0.22） vs （0.75±0.21）］ were lower than those in the control group， and the differences were statistically significant （P＜ 0.05）. There was no significant difference in the GWB score of caregivers with different care relationships. There was significant difference between groups with different care relationships （partner， parent， spring） in problem-solving ［（0.71±0.17）， （0.65±0.20）， （0.78±0.11）］ and help seeking ［（0.60±0.17）， （0.55±0.19）， （0.61±0.13）］， respectively （P＜ 0.05）. There was no significant difference between groups with different care relationships in self blame， fantasy， retreat and rationalization （P ＞ 0.05）. There was a significant positive correlation between the general well-being and problem-solving （r=0.177，P＜ 0.01）， and a negative correlation with fantasy （r=-1.03， P＜ 0.05）. Conclusions The main caregivers of schizophrenia with violence had lower general well-being and poor coping style than those without violence. The general well-being of schizophrenic primary caregivers with different violent behaviors was different， and the coping styles of primary caregivers with different care relationships were different. The general well-being of the main caregivers of violent schizophrenia was correlated with coping styles.