Objective To investigate the changes in the importance of brain function network nodes in schizophrenic patients and unaffected first degree relatives under resting state. Methods The resting-state functional magnetic resonance imaging（ rs-fMRI） were collected from 26 schizophrenia patients（ schizophrenia group） admitted to the First Affiliated Hospital of Xinjiang Medical University from October 2016 to June 2019， 21 unaffected first-degree relatives（ schizophrenia relatives group） and 22 healthy controls（ normal control group） recruited during the same period. Symptoms were assessed using the Positive and Negative Symptom Scale（ PANSS）. The voxel-based degree centrality（ DC） method was utilized to analyze the rs-fMRI data， and the variance analysis was used to compare the differences of DC values among the three groups. Finally， the correlation between the DC values in the different brain regions and the course and pathological characteristics of schizophrenia patients were analyzed. Results Compared with the healthy control group， there was significant difference in DC values of left amygdala and right superior frontal gyrus in schizophrenia group and relative group（ F=16.433， 12.218； P＜ 0.01）. The DC value of the left amygdala in schizophrenia group and relative group was lower than that in the control group， and the DC value of the right superior frontal gyrus was higher than that in the control group， the difference was statistically significant（ P＜0.05）. In addition， the DC value of multiple brain regions is related to the course of the disease and the PANSS score of the schizophrenia group （P ＜ 0.01）. Conclusions There are differences in the DC values of the left amygdala and the right superior frontal gyrus in schizophrenic patients and their unaffected first-degree relatives under resting state， suggesting that there were abnormal local connections in the brain network between the schizophrenia group and the relatives.