高低频重复经颅磁刺激交替治疗卒中后注意障碍的 疗效
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江苏省卫生健康委员会科研项目(K2019012);徐州市科技局计划项目(KC19156)


Curative effect of alternating high and low frequency repetitive transcranial magnetic stimulation (rTMS) for the treatment of post stroke attention deficits
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    摘要:

    目的 探究不同方案重复经颅磁刺激(rTMS)对卒中后注意障碍患者的治疗效果以及对神 经电生理指标的影响。方法 选取于2020 年6 月至2021 年6 月在徐州市中心医院神经康复科住院治疗 的90 例卒中后注意障碍患者为研究对象,随机分为交替组、高频组、对照组,每组30 例。3 组患者均给 予常规康复治疗,在此基础上,交替组加用1 Hz及5 Hz rTMS 交替治疗,高频组加用5 Hz rTMS 治疗,对 照组给予rTMS假刺激。于治疗前及治疗4周后采用蒙特利尔认知评估量表(MoCA)、数字广度测试(DST)、 字母划销测验和事件相关电位P300 进行测量。结果 3 组患者治疗后MoCA 评分、DST评分、注意力持 久性指数高于治疗前,P300 潜伏期短于治疗前,P300 波幅高于治疗前,差异有统计学意义(P < 0.05)。 交替组和高频组患者的治疗前后MoCA 评分差值、注意力持久性指数差值、正向DST评分差值高于对照 组[3.50(1.75,4.25)分和2.50(2.00,4.00)分比2.00(1.00,2.25)分、0.50(0.30,0.63)和0.30(0.18,0.50)比0.19 (0.10,0.29)、2.00(1.00,2.00)分和2.00(1.00,2.00)分比1.00(0,1.00)分],差异有统计学意义(P< 0.05)。 其中,交替组注意力持久性指数差值[0.50(0.30,0.63)]显著高于高频组的[0.30(0.18,0.50)],差异有 统计学意义(P < 0.05)。患者治疗前后注意力持久性指数差值与P300 潜伏期差值呈负相关(r=-0.343, P < 0.01),与P300 波幅差值呈正相关(r=0.425,P < 0.01)。结论 交替rTMS 方案和高频rTMS 方案均可 改善卒中后注意障碍患者的注意功能,交替方案对持续注意障碍的疗效更为明显,P300 可作为评估持 续注意力疗效的指标。

    Abstract:

    Objective To investigate the efficacy of different treatments of repetitive transcranial magnetic stimulation( rTMS) on post stroke attention deficits and the effects on neuroelectrophysiological indexes. Methods A total of 90 patients with post-stroke attention disorder hospitalized in the Neurological Rehabilitation Department of Xuzhou Central Hospital from June 2020 to June 2021 were selected as the research objects. They were randomly divided into alternate group, high frequency group and control group, with 30 cases in each group. On the basis of conventional rehabilitation treatment for all patients, the alternate group was treated with 1 Hz and 5 Hz rTMS alternately, the high frequency group was treated with 5 Hz rTMS, and the control group was given rTMS sham stimulation. The Montreal Cognitive Assessment( MoCA), the Digital Span Test, the Letter Deletion Test, and the Event-Related Potential P300 were assessed before and after 4 weeks of treatment. Results The MoCA score, digit span test score and attention persistence index of the three groups after treatment were higher than those before treatment. In addition, P300 latency was shorter than that before treatment, and P300 amplitude was higher than that before treatment, the differences were statistically significant( P<0.05). The difference of MoCA score, attention persistence index and positive DST score in the alternate group and high frequency group before and after treatment were higher than those in the control group[ 3.50( 1.75, 4.25) and 2.50( 2.00, 4.00) vs 2.00( 1.00, 2.25); 0.50( 0.30, 0.63) and 0.30( 0.18, 0.50) vs 0.19( 0.10, 0.29); 2.00( 1.00, 2.00) and 2.00( 1.00, 2.00) vs 1.00( 0, 1.00)], and the differences were statistically significant( P<0.05). Among them, the difference of attention persistence index[ 0.50( 0.30, 0.63)] in the alternate group was significantly higher than that in the high frequency group[ 0.30( 0.18, 0.50)], and the difference was statistically significant( P<0.05). The difference of attention persistence index before and after treatment was negatively correlated with the difference of P300 latency( r=-0.343, P < 0.01), and positively correlated with the difference of P300 amplitude( r=0.425, P<0.01). Conclusions Both alternating and highfrequency treatments can improve attention in patients with post stroke disturbance of attention. The alternating treatment is more effective for sustained attention deficits, and P300 can be used as an index to assess the efficacy of sustained attention.

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徐丙怡,巩尊科,王翔,王世雁,温炜婷,朱慧,闫金秋.高低频重复经颅磁刺激交替治疗卒中后注意障碍的 疗效[J].神经疾病与精神卫生,2022,22(4):
DOI :10.3969/j. issn.1009-6574.2022.04.009.

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  • 在线发布日期: 2022-04-25