Curative effect of alternating high and low frequency repetitive transcranial magnetic stimulation (rTMS) for the treatment of post stroke attention deficits
Objective To investigate the efficacy of different treatments of repetitive transcranial magnetic stimulation( rTMS) on post stroke attention deficits and the effects on neuroelectrophysiological indexes. Methods A total of 90 patients with post-stroke attention disorder hospitalized in the Neurological Rehabilitation Department of Xuzhou Central Hospital from June 2020 to June 2021 were selected as the research objects. They were randomly divided into alternate group, high frequency group and control group, with 30 cases in each group. On the basis of conventional rehabilitation treatment for all patients, the alternate group was treated with 1 Hz and 5 Hz rTMS alternately, the high frequency group was treated with 5 Hz rTMS, and the control group was given rTMS sham stimulation. The Montreal Cognitive Assessment( MoCA), the Digital Span Test, the Letter Deletion Test, and the Event-Related Potential P300 were assessed before and after 4 weeks of treatment. Results The MoCA score, digit span test score and attention persistence index of the three groups after treatment were higher than those before treatment. In addition, P300 latency was shorter than that before treatment, and P300 amplitude was higher than that before treatment, the differences were statistically significant( P<0.05). The difference of MoCA score, attention persistence index and positive DST score in the alternate group and high frequency group before and after treatment were higher than those in the control group[ 3.50( 1.75, 4.25) and 2.50( 2.00, 4.00) vs 2.00( 1.00, 2.25); 0.50( 0.30, 0.63) and 0.30( 0.18, 0.50) vs 0.19( 0.10, 0.29); 2.00( 1.00, 2.00) and 2.00( 1.00, 2.00) vs 1.00( 0, 1.00)], and the differences were statistically significant( P<0.05). Among them, the difference of attention persistence index[ 0.50( 0.30, 0.63)] in the alternate group was significantly higher than that in the high frequency group[ 0.30( 0.18, 0.50)], and the difference was statistically significant( P<0.05). The difference of attention persistence index before and after treatment was negatively correlated with the difference of P300 latency( r=-0.343, P < 0.01), and positively correlated with the difference of P300 amplitude( r=0.425, P<0.01). Conclusions Both alternating and highfrequency treatments can improve attention in patients with post stroke disturbance of attention. The alternating treatment is more effective for sustained attention deficits, and P300 can be used as an index to assess the efficacy of sustained attention.
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徐丙怡,巩尊科,王翔,王世雁,温炜婷,朱慧,闫金秋.高低频重复经颅磁刺激交替治疗卒中后注意障碍的 疗效[J].神经疾病与精神卫生,2022,22(4): DOI :10.3969/j. issn.1009-6574.2022.04.009.