Transcranial magnetic stimulation （TMS）， as a common therapeutic technique for major depression， has been fully confirmed regarding to its efficacy and safety. Whereas a proportion of patients with depression do not respond to standard TMS. This may be due to the high heterogeneity of individual brain structure and function in patients with depressive disorders， resulting in patients' insensitivity to TMS with traditional localization and fixed parameters. Currently， neuroimaging and neuro-electrophysiological techniques have been applied to the localization of TMS stimulation targets to realize the individualization of TMS treatment and improve the outcomes. This review summarizes the individualized treatment protocols in current studies， in order to provide ideas for the clinical precision treatment of TMS