Objective To investigate the relationship between anxiety and depression， childhood corporal punishment experience， and life satisfaction of college students. Methods From April to May 2019， a questionnaire survey was conducted among all freshmen and sophomores of some majors in two universities in Harbin by convenient sampling method. The questionnaire includes general situation， Chinese Adolescent Student Life Satisfaction Scale（CASLSS）， Self-rating Anxiety Scale （SAS）， Self-rating Depression Scale （SDS） and Parent-Child Conflict Tactics Scale（CTSPC）. Binomial Logistic regression was used to analyze the effects of College Students' anxiety， depression， corporal punishment experience before the age of 10 and general demographic characteristics on life satisfaction. A total of 2 440 questionnaires were distributed and 2 150 valid questionnaires were recovered. The effective recovery rate of the questionnaire was 88.11%. Results The overall CASLSS score of 2 150 college students was 190（165，210）. Except academic dimension， the total score of CASLSS and the scores of all dimensions of female college students were higher than those of male college students. The difference was statistically significant （P ＜ 0.05）. The total score and each dimension score of CASLSS of college students with anxiety， depression and corporal punishment experience before 10 years old were lower than those without anxiety， depression nor corporal punishment experience before 10 years old. The differences were statistically significant （all P＜ 0.01）. Binominal Logistic regression analysis showed that anxiety status （OR=2.108， 95%CI=1.472-3.020）， depression（OR=5.831， 95%CI=4.595-7.398）， corporal punishment before 10 years old （OR=2.249， 95%CI=1.849-2.736）， male （OR=1.393， 95%CI=1.149- 1.689） were the risk factors of college life satisfaction （P ＜ 0.05）. High family monthly income （OR=0.789， 95%CI=0.697-0.892） was a protection factor of college students' life satisfaction. Conclusions The life satisfaction of college students with anxiety， depression and corporal punishment in childhood is low. Therefore， the intervention of anxiety and depression should be strengthened to improve the life satisfaction of college students.