Objective To explore the clinical characteristics and related factors of somatization symptoms in patients with depression at different ages. Methods A total of 1 503 outpatients from 11 hospitals in China from September 2014 to April 2015 were selected as the research subjects. Patient Health Questionnaire-15 （PHQ-15） and Brief 16-Item Quick Inventory of Depressive Symptomatology Self-Report （QIDS-SR16） were applied to assess the somatization symptoms and the severity of depressive symptoms. PHQ- 15 score less than 5 points means no somatization symptoms， and greater than or equal to 5 points means somatization symptoms. Spearman correlation was used to analyze the relationship between somatization symptoms and general demographic data and disease-related data in patients with depression. Age stratification was carried out at 18 to 39 years old （young group）， 40 to 64 years old （middle-aged group） and over and equal to 65 years old （elderly group）. Cumulative odds Logistic regression was used to analyze the related factors of somatization symptoms in patients with depression at different ages. Results A total of 748 （49.8%） patients with depression had somatization symptoms， of which 82.6% （618/748） of the patients' somatization symptoms were fatigue or listlessness. The scores of items with back， arm， leg or joint pain， dysmenorrhea or other problems during menstruation， pain or other problems in sexual life of patients at three different ages were compared， and the difference was statistically significant （P ＜ 0.05）. Spearman correlation analysis showed that somatization symptoms in patients with depression were positively correlated with somatic diseases， types of antidepressants， sedative hypnotics， and QIDS-SR16 scores （P ＜ 0.05）， and negatively correlated with years of education， age of first attack， and antipsychotics （P ＜ 0.05）. Taking elderly group patients as a reference， cumulative odds Logistic regression analysis showed that， the types of antidepressants （OR=2.12， 95%CI=1.38-3.26）， combination with sedative hypnotics （OR=1.59， 95%CI=1.14-2.22）， combination with antipsychotics （OR=0.59， 95%CI=0.39-0.90）， and the presence of residual symptoms （OR=11.07， 95%CI=7.70-15.90） were the related factors of somatization symptoms in young patients （P＜ 0.05）. Combination with sedative hypnotics （OR=1.51， 95%CI=1.10-2.08）， combination with antipsychotics （OR=0.45， 95%CI=0.31-0.66） and residual symptoms （OR=9.59， 95%CI=6.89-13.34） were the related factors of somatization symptoms in middle-aged patients （P＜ 0.05）. Conclusions The somatization symptoms of patients with depression after treatment were different in different age groups. Identifying age-related somatization symptoms is very important for clinicians to refine the accompanying characteristics of depression and implement individualized comprehensive intervention.