酒精使用障碍家族史对男性不良饮酒行为及酒精使用障碍患病的影响
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国家自然科学基金项目(81271489);河北省自然科学基金项目(H2015206392);河北省引进国外智力项目(YZ201801)


Impact of family history of alcohol use on individual risk drinking behaviors and prevalence of alcohol use disorders
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    摘要:

    目的 探 讨 酒 精 使 用 障 碍(AUD)家 族 史 对 男 性 不 良 饮 酒 行 为 及 AUD 患 病 的 影 响。 方法 采用分层随机抽样法,于 2016 年 1— 12 月调查河北省石家庄市藁城区 10 个单位的 1 379 名在 职男职工,根据是否有 AUD 家族史分为有酒依赖家族史(PFH)组(n=452)和无酒依赖家族史(NFH)组 (n=927)。采用自制问卷、自我报告方式调查一般人口学特征和酒精使用情况;采用 AUD 筛查量表、酒精 依赖量表分别评估受试者饮酒风险水平和酒精依赖程度;采用《精神障碍诊断与统计手册第 4 版》诊断 AUD;采用流调中心抑郁自评量表、焦虑自评量表、匹兹堡睡眠质量指数评估受试者抑郁情绪、焦虑情 绪和睡眠情况。采用多因素 Logistic 回归分析发生 AUD 的危险因素。结果 PFH 组首次饮酒年龄低于 NFH组,差异有统计学意义(t=2.519,P<0.05)。PFH组经常饮酒、独自饮酒、空腹饮酒、快速饮酒、喝闷酒、 近 1 年每周饮酒 6 d、饮中度白酒、重度饮酒、饮酒后醉酒、狂饮的发生率均高于 NFH 组,差异均有统计 学意义(χ2 =50.930、11.856、19.165、26.808、11.809、49.897、39.483、19.534、63.310、21.643;均P< 0.01)。 PFH 组高风险饮酒、酒依赖、AUD 发生率高于 NFH 组[56.9%(257/452)比 34.1%(316/927)、14.4%(65/452) 比 6.8%(63/927)、52.0%(235/452)比 30.5%(283/927)],差异有统计学意义(χ2 =64.866、20.757、59.678;P< 0.01)。多因素 Logistic 回归分析显示,在控制了年龄、文化程度、职业等因素后,有 AUD 家族史是在职 男职工发生 AUD 的危险因素(OR=1.838,95%CI=1.430~2.364,P< 0.01)。结论 具有 AUD 家族史的男 性更容易发展不良饮酒行为,AUD 家族史是发生 AUD 的独立危险因素。

    Abstract:

    Objective To explore the impact of alcohol use disorder (AUD) family history on male risk drinking behaviors and prevalence of AUD. Methods A total of 1 379 male staff from 10 companies in Gaocheng District, Shijiazhuang, Hebei Province were recruited from January to December 2016 by stratified random sampling method. All the research subjects were divided into positive family history (PFH) group (n=452) and no family history (NFH) group (n=927). The general demographic characteristics and alcohol use were investigated by self-made questionnaire and self-report. The Alcohol Use Disorders Identification Test (AUDIT) and the Alcohol Dependence Scale (ADS) were used to evaluate the subjects' drinking risk level and alcohol dependence degree respectively. The fourth edition of Diagnostic and Statistical Manual of Mental Disorders (DSM- Ⅳ) was used to diagnose alcohol dependence and alcohol abuse. Self-rating Depression Scale, Selfrating Anxiety Scale and Pittsburgh Sleep Quality Index were used to evaluate the subjects' depression, anxiety and sleep. Multivariate Logistic regression was used to analyze the risk factors of AUD. Results The age of first drinking in PFH group was lower than that in NFH group, and the difference was statistically significant (t=2.519,P < 0.05). The prevalence of regular drinking, drinking alone, drinking on an empty stomach, drinking quickly, drinking sullenly, drinking more than six days a week in recent one year, drinking moderate Baijiu, drinking heavily, getting drunk after drinking and binge drinking of PFH group was higher than that of NFH group, and the differences were statistically significant (χ2 =50.930,11.856,19.165,26.808,11.809, 49.897,39.483,19.534,63.310,21.643;P< 0.01). The prevalence of high risk drinking, alcohol dependence and AUD of PFH group was higher than that of NFH group [56.9%(257/452) vs 34.1%(316/927), 14.4% (65/452) vs 6.8%(63/927), 52.0% (235/452) vs 30.5%(283/927)], and the differences were statistically significant (χ2 =64.866,20.757,59.678;P< 0.01). Multiple Logistic regression analysis showed that after controlling for age, education level, occupation, and other factors, having family history of AUD was the risk factor of AUD prevalence of male staff (OR=1.838, 95%CI=1.430-2.364). Conclusions Individuals with family history of AUD are more likely to develop bad drinking behavior. Family history of AUD is an independent risk factor for the occurrence of AUD.

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宋美,王岚,王冉,孙玲,卢文婷,甄凤亚,王硕,高媛媛,赵晓川,于鲁璐,周子璇,王学义.酒精使用障碍家族史对男性不良饮酒行为及酒精使用障碍患病的影响[J].神经疾病与精神卫生,2022,22(8):
DOI :10.3969/j. issn.1009-6574.2022.08.003.

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  • 在线发布日期: 2022-08-23