Objective To investigate the characteristics and influencing factors of cognitive deficit in schizophrenia patients with hypertensive comorbidity. Methods From December 2020 to August 2021， a total of 130 cases of stable schizophrenia patients in the inpatient department of Shandong Daizhuang Hospital were recruited as the research object， and divided into comorbid hypertension group （n=64） and non-comorbid hypertension group （n=66）. The general demographic and clinical data as well as the scores of Repeatable Battery for the Assessment of Neuropsychological Status （RBANS） were compared between the two groups. Spearman correlation was used to analyze the correlation between cognitive function of schizophrenic patients and general demographic， clinical data and comorbid hypertension. Multiple linear regression was used to analyze the influencing factors of cognitive function in schizophrenic patients. Results Compared with the non-comorbid hypertension group， the patients in the comorbid hypertension group had a longer course of schizophrenia， a larger body weight， a higher body mass index， and more brain CT abnormalities， and the differences were statistically significant （P＜ 0.05）. RBANS delayed memory score in the comorbid hypertension group was lower than that in the non-comorbid hypertension group ［（60.88±16.76） vs （68.76±15.97）］， and the difference was statistically significant （t=-2.746， P=0.007）. The score of delayed memory was negatively correlated with comorbid hypertension （r=-0.252， P＜ 0.05）. The results of multiple linear regression analysis showed that the number of years of education was the influencing factor of RBANS total score and immediate memory， visuospatial， language， attention and delayed memory （β=7.363， 1.297， 1.479， 1.575， 2.123， 1.317； P ＜ 0.05）. The course of schizophrenia was the influencing factor of immediate memory and delayed memory （β=-0.300， -0.303； P ＜ 0.05）. Family history of schizophrenia was the influencing factor of visuospatial dimension （β=-7.015， P ＜ 0.05）. Brain CT abnormalities was the influencing factor of language （β=-2.759， P ＜ 0.05）. Comorbid hypertension was the influencing factor of delayed memory （β=-6.950， P ＜ 0.05）. Conclusions Stable hypertension affects some cognitive functions of schizophrenia patients. The course of schizophrenia， years of education， family history and brain CT abnormalities may be the influencing factors of cognitive impairment in schizophrenia patients.