Objective To investigate the malnutrition status and its influencing factors in patients with first-episode schizophrenia. Methods A total of 450 first-episode schizophrenics admitted to the Wuhan Regional Psychiatric Union from January 2020 to June 2022 were selected by simple random sampling method. The general data of patients were collected after admission. According to the criteria of Nutrition Risk Screening 2002， first-episode schizophrenics were divided into malnutrition group and normal nutrition group. Univariate analysis and multivariate Logistic regression model were used to analyze the factors affecting malnutrition in firstepisode schizophrenics. Results Of the 450 first-episode schizophrenics， malnutrition accounted for 19.11% （86/450）. The results of univariate analysis showed that there were statistically significant differences between the two groups in terms of age， body mass index， spouse， osteoporosis and food refusal （t/χ2 =5.066，9.608， 5.399，4.712，11.102； P＜ 0.05）. The results of multivariate Logistic regression analysis showed that advanced age （OR=1.446，95%CI：1.148-1.823） and food refusal （OR=4.306， 95%CI：1.865-9.944） were risk factors of malnutrition （P＜ 0.01）， while high BMI （OR=0.871， 95%CI：0.782-0.871） was an protective factor （P＜ 0.05）. Conclusions The incidence of malnutrition is high in patients with first-episode schizophrenia. Advanced age and food refusal are risk factors of malnutrition， while high BMI is a protective factor.