Objective To investigate the efficacy of early intravascular embolization in the treatment of senile ruptured cerebral aneurysms (≥ 60 years old). Methods A total of 82 senile patients with ruptured cerebral aneurysms, who were admitted to the Second People's Hospital of Guiyang from January 2020 to December 2021, were selected as the study subjects. According to the timing of intravascular embolization, they were divided into three groups: ultra-early group (within 48 h after attack, n=25), early group (within 48 h to 72 h after attack, n=27) and postpone group (more than 72 h after attack, n=30). The embolizasion and complication rate of the three groups were compared. The NIHSS scores of the three groups were compared before and after the operation, and blood samples were collected before and 3 months after the operation to measure the related indexes of vascular endothelial function in the three groups, and the complication rate and prognosis of the three groups were compared. Results The comparison of embolization degree among the three groups showed that the complete embolization rate of ultra-early group was 88.00%(22/25) , which was higher than 70.37% (19/27) in the early group and 50.00% (15/30) in the delayed group (P< 0.05). The incidence of complications in the postpone group was 33.33%(10/30), higher than 4.00% (1/25) in the ultra-early group and 14.81% (4/27) in the early group, with a statistically significant difference (P< 0.05). There was no statistically significant difference in the incidence of complications between the ultra-early group and the early group (P> 0.05). The NIHSS score of ultra-early group was (2.16±0.88) , which was lower than (3.72±0.74) of the early group and (6.78±1.05) of the delayed group, and the difference was statistically significant (P< 0.05). The levels of serum vWF and ET-1 in the three groups were significantly lower than those before operation, and the level of NO was significantly higher than that before operation (P< 0.05). At 3 months after surgery, the vWF and ET-1 levels in the ultraearly group were (56.39±14.14) ng/ml and (31.76±10.57) pg/ml, which were lower than (95.72±20.33) ng/ml and (56.87±11.08) pg/ml in the postponed group, with statistically significant differences (P < 0.05). The good prognosis rate was 92.00% (23/25) in the ultra-early group, which was higher than 60.00% (18/30) and 77.78% (21/27) in the postpone group and early group, with a statistically significant difference (P < 0.05). Conclusions Intravascular embolization can achieve satisfactory results in elderly patients with cerebral aneurysms. Early and ultra-early interventional therapy can accelerate the recovery of nerve function and reduce the risk of complications.
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舒波,出良钊,甘鸿川,周顺军,刘昱甫.早期血管内介入栓塞术治疗老年脑动脉瘤的临床疗效观察[J].神经疾病与精神卫生,2023,23(2): DOI :10.3969/j. issn.1009-6574.2023.02.004.