Schizophrenia is a serious disabling mental disorder. Its pathophysiological mechanism is still unclear， and there are individual differences and heterogeneity in treatment， resulting in high social and economic burden. In this paper， we review recent updates on the variations of cytokines in schizophrenia and their therapy from multiple perspective， with the aim of understanding the relationship between schizophrenia and cytokines from the mechanism， and providing new ideas for personalized treatment of schizophrenia patients from a more multidimensional perspective in the future.