Objective To evaluate the efficacy and safety of non-invasive neuroregulatory techniques in the treatment of anxiety disorders. Methods Randomized controlled trials（RCT） on the efficacy of non-invasive neuroregulatory techniques such as transcranial direct current stimulation （tDCS）， repetitive transcranial magnetic stimulation （rTMS）， and transcranial alternating current stimulation （tACS） in patients with anxiety disorders was searched in PubMed， Embase， Cochrane Library， China National Knowledge Infrastructure， VIP Chinese Science and Technology Journal Database， and Wanfang Database. The searching time limitation is from database establishment to September 2022. Two researchers independently screen literature， extract data， and conduct quality evaluation. RevMan 5.4 and Stata 14 software were applied in the Meta-analysis. Results A total of 22 RCTs were included， 5 of which applied tDCS， 17 of which applied rTMS， and none of which applied tACS. A total of 1 216 patients were enrolled， including 611 in the control group and 605 in the experimental group. The results of Meta-analysis showed that the improvement of anxiety symptoms in experimental group treated with non-invasive neuroregulatory techniques （tDCS and rTMS） was better than that in the control group （SMD=0.87， 95%CI=0.54-1.21，P＜ 0.05）. Subgroup analysis of different neuromodulation modes showed that rTMS was better in the experimental group than in the control group （SMD=0.90， 95%CI：0.52-1.28， P＜ 0.05）. However， there was no significant difference in the effect of tDCS on anxiety symptoms between the experimental group and the control group （SMD=0.76，95%CI：-0.00-1.53， P=0.05）. Conclusions Non-invasive neuromodulation techniques can effectively improve anxiety symptoms in patients with anxiety disorders. It is worthy of further clinical verification and promotion