The management and treatment of glycolipid metabolism disorder caused by antipsychotic drugs have been a concern of clinicians in recent years. Antipsychotics will cause glycolipid metabolism disorder though influencing the balance of intestinal flora， while probiotics can maintain intestinal flora homeostasis. This paper reviews the relevant researches on the use of probiotics to treat disorders of glycolipid metabolism caused by antipsychotic drugs， to provide the basis for the treatment of such disorders in psychiatric patients.