Objective To explore the changes in discrimination and related attitudes of hospitalized patients with schizophrenia patients from 1999 to 2021. Methods Using the convenience sampling method， 136 patients with remission stage schizophrenia from August to September in 1999 and 146 patients from August to September in 2021 were selected to investigate their discrimination status and related attitudes using mental disability discrimination attitudes and experiences questionnaire. Results In 2021， the scores of the discrimination against patients with mental disorders and their families subscale in mental disability discrimination attitudes and experiences questionnaire were （62.67±11.70） among patients with schizophrenia， lower than （66.88±7.61） in 1999， and the difference was statistically significant （t=3.361， P＜ 0.01）. In 1999， the percentage of patients who answered "agree" or "strongly agree" to "social discrimination against people with mental illness has decreased significantly in the last 20 years" " social discrimination often leads families to keep the mentally ill a secret" and " the unit （school） is fair to the mentally ill” was 63.97%（87/136）、63.97%（87/136）、 36.02%（49/136）， respectively， which is lower than that of 71.91%（105/146）、78.08%（114/146）、63.70%（93/146） in 2021， with statistically significant differences （Z=5.644， 2.541 and 4.617； P ＜ 0.05）. Conclusions The situation of discrimination against schizophrenia patients has improved compared to 20 years ago， but discrimination still has a significant impact on the psychological and social life of schizophrenia patients. There is still a long way to go to improve the problem of discrimination against mental disorders.