Depression is often accompanied by pain symptoms， and common sensory pathways and neural circuits may be the reasons for the coexistence of depression and pain symptoms， providing theoretical basis and potential targets for neuroregulatory therapy. In recent years， many researches and practices of noninvasive neuromodulation such as electroconvulsive shock therapy， transcranial magnetic stimulation， transcranial electrical stimulation， transcutaneous vagal nerve stimulation， light therapy and transcranial ultrasound stimulation in the treatment of depression and pain symptoms are developing rapidly. All the above noninvasive neuromodulation therapy may provide new therapeutic choices in the treatment of depression with pain symptoms. We reviewed the progress in this field which may provide references for further research and clinical practice.