Objective To understand the current situation and influencing factors of the family burden of epilepsy in children， and to provide a basis for promoting reasonable management of epilepsy in children and reducing the family burden of epilepsy in children. Methods Parents of 315 epileptic children who were hospitalized in the Department of Neurology of Xi'an Children's Hospital from January to December 2021 were selected as the research subjects by the convenient sampling method. A self-designed general questionnaire， maternal pregnancy and childbirth situation questionnaire， disease related information questionnaire and Family Burden Scale （FBS） were applied to investigate the general information， maternal situation， disease situation and family burden status of children with epilepsy. Multiple linear regression analysis was applied to analyze the influencing factors of family burden of epilepsy in children. Results The total FBS score was （17.95±11.36）， and the standardized score of family financial burden dimension was 1.0（0.8，1.6）. The financial burden of 70.48% （222/315） of families of children with epilepsy was at a moderate or higher level. The results of multiple linear regression analysis showed that the occupation of the father， annual family income， frequency of outdoor activities， epilepsy comorbidities， frequency of seizures and multidrug therapy were all influencing factors of family burden （P ＜ 0.05）. Conclusions Among the families with epilepsy， the economic burden is the heaviest， with a moderate or higher level. Families of children with epilepsy with unstable father occupation， low family annual income， comorbidities of epilepsy， low frequency of outdoor activities， seizures not effectively controlled， and multiple drug treatment need more attention.