Acute ischemic stroke is characterized by high incidence rate， high disability rate and high recurrence rate， resulting in a high burden on the family and society. Compared with non atrial fibrillation （AF） related stroke， AF related stroke has more severe symptoms， higher disability rate， higher mortality， and easy recurrence. Due to the oversimplification of the traditional association mechanism between AF and stroke， many hypotheses have emerged regarding the mechanism of AF causing stroke， such as endothelial injury， hypercoagulable state， inflammation， atrial remodeling， and left atrial morphology. Inflammatory markers are important factors in the development of atrial fibrillation and stroke. Therefore， research on the correlation between inflammatory factors and AF related stroke is of great significance for stroke prevention in AF patients and clinical medication guidance for AF related stroke. This article mainly reviews the relationship between inflammatory factors and AF related stroke.