Parkinson disease （PD） is a common neurodegenerative disease in middle-aged and older adults. Its etiology is strongly related to degeneration， heredity， environment factors. Motor symptoms and nonmotor symptoms gradually worsen with disease progression which can reduce quality of life of patients. Drug therapy and neuromodulatory therapy are currently the main treatment methods for PD， but they can only improve the clinical symptoms of patients and can not cure the disease. There is no definite means to delay the progression of the disease. The PD prodromal warning， early diagnosis， and research on disease modification therapy is of great significance. Multidisciplinary diagnosis and treatment models and full disease cycle management involving patients can better help patients improve their quality of life. This article introduces the relevant progress in the diagnosis and treatment of PD， in order to deepen understanding of the disease， explore new treatment methods and disease management models.