Objective To explore the effect of integrated medical care model on mood disorders and sleep quality in patients with hyperthyroidism. Methods A total of 69 patients with hyperthyroidism hospitalized in the Department of Endocrinology of Handan First Hospital from August 2019 to August 2021 were selected by convenience sampling method. All the patients were divided into control group （n=34） and study group （n=35） by random number table method. The control group adopted the routine medical care mode， and the study group adopted the integrated medical care mode on the basis of medical treatment for 3 months. The changes of Depression， Anxiety and Stress Scale （DASS-21）， and Pittsburgh Sleep Quality Index （PSQI） were compared between the two groups before and after the intervention. Results Before the intervention， there was no significant difference in the scores of DASS-21 and PSQI between the control group and the study group ［（31.05±7.52） vs （30.35±6.85）， （14.91±1.94） vs （15.06±2.06）］（t=0.404， -0.369； P＞ 0.05）. After the intervention， the scores of DASS-21 and PSQI of the study group were （18.62±4.25） and （7.26±0.90）， and those of the control group were （24.95±5.25） and （10.53±1.13）. The scores of DASS-21 and PSQI after the intervention of both groups were lower than those before the intervention， and the scores of the study group were lower than those of the control group， with statistical significance （P ＜ 0.01）. Conclusions The implementation of integrated medical care model while medication treatment can effectively alleviate the negative emotions of hyperthyroidism patients and improve their sleep quality.