外泌体作为一种纳米级别的细胞外囊泡，内含多种生物活性物质，其广泛参与细胞间物 质运输与信息传递，并在多种病理生理过程中发挥重要作用。心境障碍常因其临床复杂性而导致识别 困难、诊断不明确以及治疗难度大。心境障碍患者的外泌体在数量及表型上与健康对照者相比存在差 异。现对心境障碍患者外泌体的相关研究进行综述，探讨不同来源的外泌体作为心境障碍生物诊断标 志物以及治疗靶点的可能性。
Exosomes are nanoscale extracellular vesicles containing a variety of bioactive substances that are widely involved in intercellular material transport and information transfer， and play an important role in a variety of pathophysiological processes. Mood disorders often result in difficulty in recognition， unclear diagnosis， and difficult treatment due to their clinical complexity. There are differences in the quantity and phenotype of exosomes between patients with mood disorders and healthy controls. This article reviews the relevant research on exosomes in patients with mood disorders， and explores the possibility of exosomes from different sources as biological diagnostic markers as well as therapeutic targets for mood disorders.
DOI :10.3969/j. issn.1009-6574.2023.09.012.