N-甲基-D-天冬氨酸受体2B亚基基因遗传与认知功能损害关系的研究进展
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天山创新团队计划(2022D14011)


Research progress on correlation between N-methyl-D-aspartate receptor 2B subunit gene inheritance and cognitive impairment
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    摘要:

    许多疾病在发生发展中都伴随认知功能损害,且认知功能损害对疾病病程以及预后存在 不利影响。N- 甲基 -D- 天冬氨酸受体 2B 亚基(GRIN2B)基因与突触可塑性有关,故其与认知功能损害 有潜在联系。本文从GRIN2B基因表达、基因多态性以及表观遗传学等方面与认知功能损害的相关研 究进行综述,探讨产生认知功能损害的潜在机制。

    Abstract:

    Many diseases are accompanied by cognitive impairment during their occurrence and development, and cognitive impairment has adverse effects on the course and prognosis of the disease. The N-methyl-D-aspartate receptor 2B subunit (GRIN2B) gene is associated with synaptic plasticity and therefore has a potential association with cognitive impairment. This article reviews the research on the correlation between GRIN2B gene expression, gene polymorphism, and epigenetics with cognitive impairment, in order to explore the potential mechanisms of cognitive impairment.

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余浩,邹韶红. N-甲基-D-天冬氨酸受体2B亚基基因遗传与认知功能损害关系的研究进展[J].神经疾病与精神卫生,2023,23(9):
DOI :10.3969/j. issn.1009-6574.2023.09.013.

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  • 在线发布日期: 2023-10-24