Objective To explore the efficacy of repetitive transcranial magnetic stimulation (rTMS) combined with ziprasidone on cognitive function in patients with convalescent schizophrenia. Methods A total of 210 patients with convalescent schizophrenia admitted to the Outpatient Department of Shandong Mental Health Center from January 2019 to December 2021 were selected as the research subjects. The patients were randomly divided into a control group and an observation group by the random number table method, with 105 cases in each group. The patients of control group were treated with ziprasidone, while the patients of observation group were given rTMS on the basis of the control group, with each group receiving treatment for 12 weeks. The Positive and Negative Syndrome Scale (PANSS) scores and the Schizophrenia Cognition Rating Scale (SCoRS) scores before and after treatment, and the Treatment Emergent Symptom Scale(TESS) scores during treatment were compared between the two groups. Results After 12 weeks of treatment, the total effective rate of the observation group was 89.52% (94/105), higher than the control group's 79.05% (83/105), with a statistically significant difference (P < 0.05). The PANSS subscale scores and SCoRS scores of the two groups of patients after treatment were lower than those before treatment, and the PANSS subscale scores and SCoRS scores of the observation group after treatment were lower than those of the control group, with statistically significant differences (P < 0.05). Conclusions The combination of rTMS and ziprasidone has a significant efficacy in patients with convalescent schizophrenia, which can effectively improve their cognitive function.
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崔翠翠,陈珍利,李翠鸾,韩丽,吴雪飞,李晓靖.重复经颅磁刺激联合齐拉西酮对康复期精神分裂症患者认知功能的疗效[J].神经疾病与精神卫生,2023,23(10): DOI :10.3969/j. issn.1009-6574.2023.10.006.