卒中后认知障碍和睡眠障碍认知损害的脑网络及事件相关电位研究进展
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河北省高等学校自然科学研究重点项目(ZD2020349);河北省医学科学研究课题计划(20201283)


Research progress on brain network and ERP in post-stroke cognitive impairment and sleep disorders cognitive impairment
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    摘要:

    卒中后认知障碍(PSCI)和睡眠障碍认知损害为卒中和睡眠障碍的常见并发症,两者均与 认知相关脑网络重构密切相关。PSCI、睡眠障碍认知损害事件相关电位(ERP)主要表现为 P300 成分潜 伏期延长和波幅降低,提示注意力、记忆力和执行控制功能受损。本文分别从 PSCI、睡眠障碍认知损害 与脑网络重构的关系及 ERP 变化特征进行阐述,在脑网络和神经电生理水平探讨 PSCI、睡眠障碍认知 损害的机制和特征,旨在临床干预 PSCI、睡眠障碍认知损害,改善临床结局。目前,卒中相关睡眠障碍 (SSD)认知损害与脑网络重构的关系和 ERP 变化特征的系统报道较少,同步应用神经影像和神经电生理 在时间和空间维度探寻 SSD 认知损害的机制和特征可能是今后的研究热点方向之一。

    Abstract:

    Poststroke cognitive impairment (PSCI) and sleep disorders cognitive impairment are common complications of stroke and sleep disorders, both of which are closely associated with cognitive related brain network reconstruction. PSCI and sleep disorder cognitive impairment event-related potentials (ERP) are mainly characterized by prolonged latency and reduced amplitude of P300 components, indicating impaired attention,memory, and executive control functions. This article elaborates on the relationship among PSCI, sleep disorders cognitive impairment, and brain network reconstruction, as well as the characteristics of ERP, and explores the mechanisms and characteristics of PSCI and sleep disorders cognitive impairment at the level of brain network and nervous electrophysiology, aiming to intervene in PSCI and sleep disorders cognitive impairment and improve clinical outcomes. At present, there are few systematic reports on the relationship between cognitive impairment in stroke related sleep disorders (SSD) and brain network reconstruction, as well as the change characteristics of ERP. The simultaneous application of neuroimaging and nervous electrophysiology to explore the mechanisms and characteristics of SSD cognitive impairment in both temporal and spatial dimensions may be one of the future research hotspots.

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钱洪春,张萍淑,元小冬,袁建新,曹凌云,段丽琴.卒中后认知障碍和睡眠障碍认知损害的脑网络及事件相关电位研究进展[J].神经疾病与精神卫生,2023,23(10):
DOI :10.3969/j. issn.1009-6574.2023.10.011.

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  • 在线发布日期: 2023-12-01