Bipolar disorder is a serious mental disorder， often characterized by circadian rhythm disorders， insomnia， excessive sleep， and other symptoms， and its occurrence and development are influenced by genetic factors. Sleep disorders manifest as circadian rhythm disorders， insomnia， and other symptoms， which are also related to genetics. The genetic mechanisms of bipolar disorder and sleep disorders overlap. This paper reviews the co-pathogenic genes of bipolar disorder and sleep disorders， looks back the genetic association between the two diseases， summarizes potential co-pathogenic genes， so as to provide new ideas for the occurrence， development， prevention， and treatment of diseases.