Fatigue is a common symptom in patients with multiple sclerosis， characterized by subjective exhausted and insufficient physical and/or mental energy. It is an important cause of disability and unemployment， seriously affecting the quality of life of patients with multiple sclerosis. Psychological disorders are one of the important reasons for the persistence and deterioration of fatigue in patients with multiple sclerosis. Previous studies have explored psychological interventions for multiple sclerosis fatigue， such as cognitive-behavioral therapy， mindfulness therapy， relaxation therapy， self-management projects， and guiding imagination， which have shown certain effects in improving fatigue in multiple sclerosis patients. This paper reviews the psychological intervention methods and effects on fatigue in multiple sclerosis patients both domestically and internationally， aiming to provide theoretical basis for future research on psychological intervention for fatigue in patients with multiple sclerosis.