Meningioma is the most common primary tumor of the central nervous system， which can mostly be cured through surgical resection， radiotherapy， and chemotherapy. The recurrence rate of meningioma is relatively high， with an overall recurrence rate of 10% to 20%. At present， exploring the mechanism of meningioma recurrence is a research hotspot. This article reviews the research progress on molecular characteristics of meningioma recurrence， including chromosome copy number， genome， proteome， and epigenetics， so as to provide accurate molecular markers for the diagnosis， treatment， and prognosis of meningioma.