1型发作性睡病与精神分裂症相关性及治疗的研究进展
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Research progress on the correlation and treatment between narcolepsy type 1 and schizophrenia
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    摘要:

    1 型发作性睡病(NT1)以脑脊液中下丘脑食欲素 -1(Hcrt-1)水平下降为重要指标。NT1 主 要的临床表现为不可抑制的日间过度思睡(EDS)、猝倒发作、睡眠瘫痪、夜间睡眠紊乱,同时常伴有入睡 前生动的幻觉等精神病性症状。NT1 患者的精神病性症状复杂多样,而精神病性症状也是精神分裂症 的核心症状,这可能会对两者的诊断及治疗造成困难。本文对 NT1 患者精神病性症状与精神分裂症的 相关性及治疗方案进行综述,以期提高临床医生对两者的鉴别能力,提高对两者存在共病可能性的认 识,为患者提供更有效的治疗。

    Abstract:

    Type 1 narcolepsy is characterized by the decrease of hypocretin-1 level in cerebrospinal fluid. The main clinical manifestations of NT1 type are uncontrollable excessive daytime sleepiness, cataplexy, sleep paralysis, sleep disorder at night, and often accompanied by psychotic symptoms such as hallucinations before falling asleep. The psychotic symptoms of NT1 patients are complex and diverse, and psychotic symptoms are also the core symptoms of schizophrenia, which may bring difficulties to the diagnosis and treatment of both. Therefore, this article reviews the correlation between psychotic symptoms and schizophrenia in patients with NT1 and the treatment plan, in order to improve the clinicians' ability to identify them,improve their understanding of the possibility of comorbidity,reduce the misdiagnosis rate, and provide more effective treatment for patients.

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郭静仪,李艳红,帅军君.1型发作性睡病与精神分裂症相关性及治疗的研究进展[J].神经疾病与精神卫生,2024,24(1):
DOI :10.3969/j. issn.1009-6574.2024.01.010.

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  • 在线发布日期: 2024-02-01