脑血流动力学改变与认知功能障碍相关性的研究进展
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国家自然科学基金(81901084)


Research progress on correlation between changes in cerebral hemodynamics and cognitive dysfunction
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    摘要:

    脑血流动力学改变在血管源性认知障碍的发生过程中扮演着重要角色,脑血流动力学受 脑血流变化、血管搏动、颅内压变化、颅内顺应性、脑灌注压和自动调节影响,当发生脑血流低灌注、动 脉硬化、神经血管单元失衡时,临床表现为认知障碍。目前临床诊疗中可借助超声、功能近红外光谱、 脑计算机断层扫描灌注、磁共振、正电子发射断层成像评估脑血流动力学。本文通过探讨脑血流动力 学改变致认知障碍的病理生理学机制、临床评估技术、临床特点和治疗干预措施,旨在加深临床医师对 此类疾病的认识和理解,寻找可靠预测指标,从而识别高危个体,以便及早干预。

    Abstract:

    Changes in cerebral hemodynamics play an important role in the process of vascular cognitive impairment, cerebral hemodynamics are influenced by changes in cerebral blood flow, vascular pulsation, intracranial pressure, intracranial compliance, cerebral perfusion pressure, and autoregulation. When cerbral blood flow hypoperfusion, arteriosclerosis, and imbalance of neurovascular units occur, the clinical manifestation is cognitive impairment. At present, clinical diagnosis and treatment can rely on ultrasound, functional near-infrared spectroscopy, brain computed tomography perfusion, magnetic resonance imaging, positron emisson tomography to evaluate cerebral hemodynamics. This paper explores the pathophysiological mechanisms, clinical evaluation techniques, clinical characteristics, and treatment interventions of cognitive impairment caused by changes in cerebral hemodynamics, aiming to deepen the understanding of this disease among clinical physicians, search for reliable predictive indicators, and identify high-risk individuals for early intervention.

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严一丹,章腾,杨素新,唐铁钰,许笑天.脑血流动力学改变与认知功能障碍相关性的研究进展[J].神经疾病与精神卫生,2024,24(3):
DOI :10.3969/j. issn.1009-6574.2024.03.009.

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  • 在线发布日期: 2024-04-07