Histone deacetylase 3 (HDAC3) is an epigenetic negative regulatory factor associated with cognitive impairment, widely expressed in the amygdala, hippocampus, and cortex. The activated HDAC3 has neurotoxic effects and negatively regulates the formation of cognition and memory. This paper reviews the mechanism of HDAC3 in cognitive impairment and explores the development prospects of HDAC3 inhibitor therapy.
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蔡凌宇,刘媛媛,任江滨,苏鸿,孙晓阳. HDAC3在认知功能障碍中的研究进展[J].神经疾病与精神卫生,2024,24(4): DOI :10.3969/j. issn.1009-6574.2024.04.008.